Curriculum Vitae

PROFILE

Committed professional with over ten years of experience in technology, life science, and related health care fields.  Ability to work across many disciplines and with people at all levels of responsibility.  Excellent management of client/partner relationships even when working in remote locations or offices.  Exceptional analytical and organizational skills gained from nine years of work in academic, industrial, and government environments.  Able to successfully enter a new field and rapidly understand the underlying issues and subtleties, proven by diverse variety of projects managed across different software platforms and subject areas.  Excellent writing and communication abilities, demonstrated by over twenty five publications and six invited speaking opportunities.

PROFESSIONAL EXPERIENCE

1/2009-present date

Self Employed

Principle responsibilities: Creating custom software solutions built upon open source solutions using agile methods for a variety of small business clients.  Worked with five different clients in three countries to analyze business needs and develop comprehensive technical solutions, including cost estimates, project planning, and hands-on implementation.

Samples of work:

Installation, design, and custom configuration of open source Content Management Systems, including Joomla, Magento, Mediawiki, and Drupal.  Excellent understanding of HTML and CSS.  Working understanding of PHP and MySQL.  Administration of email clients, website domains and hosting services using tools such as FTP, SSH, and CPanel.  Migrated several clients’ websites from one hosting provider to another.  Analysis of existing websites to develop comprehensive plan for CMS upgrade and design improvements.  Development and implementation of comprehensive plans for Search Engine Optimization and content development.  Specialized in Google Analytics, Webmaster Tools, AdWords, and AdSense.   Samples of work:  Joomla websites: http://jamesstreetassoc.com, http://retirementdetectives.com, http://aroslaw.com, http://www.creativequiltersofcitruscounty.comMagento website: http://perfectlypackedinc.comMediawiki website: http://www.drivetheamericas.comDrupal website (still under development): http://beta.drivetheamericas.com

9/2006-7/2008, Washington, DC

Science & Technology Policy Fellow, American Association for the Advancement of Science (AAAS)
U.S. Department of Health and Human Services (HHS)
Immediate Office of the Secretary

Principle responsibilities: Work to achieve the goals of HHS Secretary Michael O. Leavitt’s Personalized Health Care (PHC) Initiative through: policy analysis and research; development of options papers to inform policy, legislative, and regulatory decisions; management of the activities of related workgroups; facilitation of inter-agency collaborations; and outreach to non-governmental stakeholders.

• Identified expert testimony, facilitated presentation development, and organized panel presentation on PHC for the American Health Information Community (AHIC), a federal advisory committee body chaired by Secretary Leavitt.  This resulted in the formation of a PHC working group tasked with facilitating the incorporation of genetic information and analytical tools in electronic health records.
• Conducted research, identified appropriate expert testimony, and organized monthly meetings of the PHC workgroup of the AHIC.  Drafted vision summary and priorities documents based on these meetings that were reviewed and accepted by the PHC workgroup, are being used to guide recommendations development, and were presented to the AHIC.
• Led collaborative meetings between the PHC workgroup and the other relevant experts, including the National Institutes of Health (NIH), Harvard Medical School, private health care providers, and standards development organizations, to conduct an environmental scan in the area of medical genetic tests, family health history, and newborn screening.  Based on the testimony and environmental scans, drafted recommendations that were presented to and accepted by the AHIC.
• Led meetings with federal health care providers and public health services agencies, including the Department of Veteran’s Affairs (VA), Department of Defense (DoD), Indian Health Services (IHS), Centers for Disease Control and Prevention (CDC), Office of the Surgeon General (OSG), National Human Genome Research Institute (NHGRI), in coordination with the PHC workgroup, to provide background on electronic tools to record family medical history information.  Drafted recommendations that these stakeholders coordinate their electronic family history tool development and implementation to assure interoperability, which were accepted the AHIC.
• Conducted research on legislative options and regulatory authorities relative to the evidence development and oversight of genomic testing technologies, and developed a position paper on these issues that was presented to Secretary Leavitt.
• Followed movement of the Genetic Information Non-Discrimination Act (GINA) of 2007 through the House of Representatives, and submitted comments to and answered questions from the Assistant Secretary of Legislative Affairs relative to GINA.  Some suggestions were accepted in committee, included in the final version of the bill which passed the House of Representatives 420-3, and was signed in to law in 2009.

9/2004-8/2006, Emeryville, CA
Post-Doctoral Fellow
Chiron Corp. (now Novartis)
Departments of Bioorganic Chemistry and Medicinal Chemistry
Principle responsibilities: Synthetic organic chemist working as a team member with both the bioorganic and medicinal chemistry departments of Chiron Corp to develop new synthetic methods, improve solid phase synthetic techniques, and perform lead optimization.

• As part of the medicinal chemistry team optimizing the activity of novel anti-cancer agents, developed a new method to prepare a key intermediate for the synthetic scheme that was accepted for scale-up by the process group, submitted for publication, and was recognized by a Chiron Contribution Award.
• Within the bioorganic chemistry group, worked as part of a team to optimize the scale-up and synthesis of a novel linker that could be used to identify lead compounds in protein binding assays, resulting in the validation and publication of the methodology.
• Worked with the bioorganic chemistry and biology teams to optimize the synthesis of a lead compound that could be used to detect variant Creutzfeldt-Jakob disease (mad cow disease) in blood samples.  Synthesized a series of related compounds to better understand the activity of this class of compounds, optimized the large scale synthesis of the lead compound, resulting in a highly active and sensitive assay.

9/1999-6/2004, Berkeley, CA
Graduate Student
University of California, Berkeley
Department of Chemistry and Chemical Engineering

Principle responsibilities: Led three independent organic chemistry research projects; presented research to the chemistry department; completed five graduate level classes in organic, physical organic, bioorganic, and combinatorial chemistry; and mentored graduate students and undergraduates both in the laboratory and as a graduate student instructor.

Led project, working with academic and industrial partners, to investigate novel anti-malarial agents.  Systematically optimized the activity of an initial hit compound using medicinal and organic chemistry techniques by synthesizing 25 rationally designed analogous compounds, resulting in highly potent and selective compounds that killed the parasite that causes multi-drug resistant malaria, showed promising initial activity in mouse malaria models, and published two papers describing the work.

• Developed and optimized a rapid and novel methodology to synthesize a class of pharmaceutically important compounds, demonstrated the usefulness and generality of the methodology through the synthesis of a diverse variety of related compounds, and applied the methodology to the synthesis of a complex natural product, resulting in an improved synthesis of the natural product and the publication of these results.
• Served as a mentor and teacher throughout graduate school.  Mentored four undergraduate students who each independently worked on a summer-long synthetic organic chemistry project; two of these undergraduates proceeded to attend graduate school in organic chemistry, and the other two attended medical school.  Additionally, served as a graduate student instructor in two advanced undergraduate synthetic and physical organic chemistry classes, and was given an Outstanding Graduate Student Instructor Award for these efforts.

8/1997-8/1999, Medford, MA
Scientist
ArQule, Inc.
Department of Biochemistry
Principle responsibilities: Develop biochemical assays, adapt the assays for high throughput screening, screen combinatorial libraries for activity against a variety of targets, and present research to the biochemistry team.

Developed UV-vis, fluorescence resonance energy transfer, and scintillation proximity assays and subsequently adapted them for high throughput screening, resulting in the identification of several promising lead compounds.
Worked with the information technology team to adapt robotic equipment and instrumentation to develop a fully automated turbidimetric assay to evaluate solubility of combinatorial libraries in a variety of buffers.

EDUCATION

• 12/2004: Ph.D. in Chemistry, University of California, Berkeley
• 5/1997: B.A. in Chemistry, Haverford College

HONORS

• 9/2006-7/2008: AAAS Science and Technology Policy Fellowship
• 11/2005: Chiron Contribution Award
• 5/2001: Outstanding Graduate Student Instructor Award
• 4/1999: Honorable Mention, NSF Predoctoral Fellowship
• 5/1997: Graduated with Honors in Chemistry from Haverford College
• 5/1997: Colin F. MacKay Prize in Chemistry
• 5/1996-5/1997: Howard Hughes Interdisciplinary Scholarship

SPEAKING OPPORTUNITIES

• 4/1/2011: Roundtable panelist and exhibitor at Overland Expo: http://www.ovexpo.com/
• 6/19/2008: Annual Meeting of America’s Health Insurance Plans (AHIP): Personalized Medicine: Clinical Advancements Create a New Paradigm”
• 6/11/2008: Cambrige Healthtech Institute 9th Annual Beyond Genome Conference – Tools to Therapy: “The American Health Information Community’s Personalized Health Care Workgroup”
• 2/8/2008: AdvaMed Medical Technology Learning Institute:“Panel Discussion: Regulation of Biomarkers & Molecular Diagnostic Products”
• 12/12/2007: Utah Technology Council Meeting: “Secretary Leavitt’s Personalized Health Care Initiative”
• 8/29/07: Public Health Information Network Annual Conference – Plenary: Office of the National Coordinator Perspectives, “Personalized Health Care”

ONLINE PUBLICATIONS

• Published a ten-part weekly series describing my travels through Latin America: http://www.newsroompanama.com/travel.html
• Published five articles about retiring in Ecuador: http://retirementdetectives.com/ecuador.html
• Wrote a popular blog about our travels through Latin America: http://www.thedarienplan.com
• Published thirteen papers in prestigious scientific journals between 1999 and 2007

PUBLICATIONS

• Brinner, K. M.; Doughan, B., Poon, D. “Scaleable Synthesis of b-Amino Esters via Reformatsky reaction with tert-Butanesulfinyl Imines” Synlett, 2009, (6), 991.
• Brinner, Kristin M.; Downing, Gregory J. “Advancing Patient-Centered Pediatric Care Through Health Information Exchange: Update From the American Health Information Community Personalized Health Care Workgroup” Pediatrics, 2009, (123 Suppl.), 122.
• Downing,  Gregory J; Boyle, Scott N; Brinner, Kristin M; Osheroff, Jerome A. “Information Management to Enable Personalized Medicine: Stakeholder Roles in Building Clinical Decision Support” BMC Medical Informatics and Decision Making 2009, (9), 44.
• Feero, W. G.; Bigley, M. B.; Brinner, K. M. “New Standards and Enhanced Utility for Family Health History Information in the Electronic Health Record: An Update from the American Health Information Community’s Family Health History Multi-Stakeholder Workgroup “ JAMIA, 2008, (15), 723.
• Glaser, J.; Henley, D. E.; Brinner, K. M.  “Advancing Personalized Health Care Through Health Information Technology: An Update from the American Health Information Community’s Personalized Health Care Workgroup“  JAMIA, 2008, (15), 391.
• Machajewshi, T.; et al (Brinner, K.). ”2-Amino-7,8-Dihydro-6H-pyrido[4,3-H]-Pyrmidin-5-ones“ Patent WO2007041362, April 12, 2007.
• Paulick, M. G.; Hart, K. M.; Brinner, K. M. et al  “A Cleavable Hydrophilic Linker for One-Bead-One-Compound Sequencing of Oligomer Libraries by Tandem Mass Spectrometry”  J. Comb. Chem, 2006, 8(3) 417.
• Nenajdenko, V. G.; Korotchenko, V. N.; Shastin, A. V.; Balenkova, E. S.; Checked by Brinner, K. M.; Ellman, J. A. “Conversion of Arylalkylketones into Dichloroalkenes : (1-chloro-4-(2,2,-dichloro-1-methylethenyl)-benzene)” Org. Syn, 2005, 82, 93.
• Brinner, K. M.; Ellman, J. A. “A Rapid and General Method for the Asymmetric Synthesis of 2-Substituted Pyrrolidines using tert-Butanesulfinamide” Org. Biomol. Chem. 2005, 3, 2109.
• Brinner, K. M.; Ellman, J. A. “Asymmetric Synthesis of b-Amino Acids by Enolate Additions to tert-Butanesulfinyl Imines” in Enantioselective Synthesis of b-Amino Acids, 2nd Edition, Juaristi, E.; Soloshonok, V. Eds;  Wiley-VCH, New York, 2005.
• Brinner, K. M.; Powles, M.; Schmatz, D.; Ellman, J. A. “Potent 4-Aminopiperidine Based Antimalarial Agents” Bioorg. Med. Chem. Lett. 2005,15(2), 345.
• Brinner, K. The Synthesis and Evaluation of Novel and Potent Anti-Malarial Compounds; The Synthesis of 2-Substituted Pyrrolidines using tert-Butanesulfinamide; The Total Synthesis of Antofine.  PhD Thesis, University of California, Berkeley, Berkeley CA, 2004.
• Brinner, K. M.; Kim, J. M.; Habashita, H.; Gluzman, I. Y.; Goldberg, D. E.; Ellman, J. A. “Novel and Potent Antimalarial Agents” Bioorg. Med. Chem. 2002, 10(11), 3649.

PERSONAL WEBSITES

• http://www.thedarienplan.com: Blog chronicling our travels by car from California to Argentina in our Honda Element.  The blog had over 140 subscribers and averaged 100 hits/day.
• http://www.drivetheamericas.com: During our travels throughout Latin America, we were frustrated by the lack of information on border crossings, road conditions, gas prices, and campsites.  We built a comprehensive website for other people traveling Latin America by car.  The website continues to grow with over 100 registered users and and averages over 100 hits/day.